CRC incidence and mortality among older adults has been declining for several decades due to increased uptake of screening. This significant increase in young-onset CRC is thought to correlate, among others, with increase in the prevalence of obesity and diabetes, well-described risk factors for CRC.
Thus, the findings of this study from Low and colleagues come as a surprise. In a case-control study of 68, U. Being overweight or obese was associated with a decreased risk for CRC. In fact, weight loss over the preceding 5 years prior to cancer diagnosis was correlated to diagnosis of CRC, with Other independent risk factors included age, smoking, male sex and nonuse of aspirin.
The authors point out that weight loss preceded the diagnosis of young-onset CRC. While this may seem contrary to previous studies showing a correlation between young-onset CRC and overweight and obesity, this study examines a population that already has developed CRC and, in some cases, advanced disease data not available. In fact, prior research has shown that young-onset CRC is more likely to present at an advanced stage than patients with older-onset CRC.
Thus, the research by Low and colleagues is consistent with published data. A take-away point from this study of a large national sample of veterans is that significant weight loss should trigger a thorough evaluation even in younger patients. It does not refute the notion that obesity, overweight and even Western-style diet as noted in another presentation at DDW, are risk factors for CRC.
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These include fatigue lack of energy , weakness, and difficulty in performing everyday tasks. There are some different ways of how a cancer can lead to weight change. Even the place of where it grows can have an effect, too. Some experts believe that the cancerous cells may use up much of the energy in the body. They may also affect the metabolism or the way of the body in making energy from food.
Another interesting issue, the cancer often affects the appetite level of patient. Even many of them experience a significant appetite loss. And if you have lack of appetite, you tend to eat less than usual, causing weight loss. But over time, the cancerous growth can be large enough to cause extra pressure inside colon, causing some discomforts.
However, these symptoms can pinpoint numerous different health conditions, too. How about changes in weight? As mentioned earlier, most cancers can lead to weight loss, including colon cancer. It may occur in the early stages of the cancer — or much later in the advanced stages.
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