Well, this occurs due to the fact that phosphorylation can keep a molecule from diffusing out of its position; making it more reactive by borrowing a phosphate molecule from ATP. In g3p dehydrogenase. How oxygen is attached to po3 from where it come.. It is a non enzymatic reaction. Therefore 1 for oxidation of Nadh 2 High energy of electron is then produce ATP, and as a terminal acceptor of electron, O2 is required.
Hope this is clear. Because there are free floating inorganic phosphates in the cytosol of the cell that are used for the phosphorylation of that substrate where ATP is not required. Thank you very much. This is a great survey of glycolysis. Thanks so much! I shared it with all my classmates. I hope your page gets sore from all the web hits it is gonna get!
Thanks I appreciate this impressive literature ,quite educative we need more of this concerning glycogen. Please i want to understand how the net yield of 8ATPs in aerobic glycolysis is realized. Thank you. Thank God I came across this.. Even better than my textbooks..
In the last step where phosphoenol pyruvate is converted to pyruvic acid! Where is the Hydrogen atom coming from? Thank you very much, I thought triose phosphate was the main intermediate which continues glycolysis. Thanks fr clearing this dilemma.
Honestly, I can feel how you really want to let the readers understand the concepts in a friendly language to help them keep up with every step. Thanks a lot! Honestly this is amazing. Thanks alot. In simple words most of the food items contains glucose or its combined forms like sucrose. To be honest before I found this, I suffered a lot on how to understand this thing. Thank You so much. Do you have the same excelently written Krebs Cycle as you have done in the glycolisis cycle?.
You have done an outstanding job. Well written notes. Please mark on structure how the six carbon breaks into 3carbons compounds in step 4. Kindly describe the process in the mitochondria as well.
Also please do the same for gluconeogenesis, glycogenesis and glucogenolysis. I like the way all the steps have been outlined for easy understanding. I found this very helpful. With some level of effort, I now have all the 10 steps on my finger tips for my biochemistry class. Thank you so much for sharing. I have a doubt,from where does the phosphate in step 6 come from? It just says that phosphate is added. Anyway the answer was useful,Thank you! In the process, a phosphate group from ATP is transferred to glucose producing glucose 6-phosphate or G6P.
One molecule of ATP is consumed during this phase. The enzyme phosphoglucomutase isomerizes G6P into its isomer fructose 6-phosphate or F6P.
Isomers have the same molecular formula as each other but different atomic arrangements. Two ATP molecules have been used so far. The enzyme aldolase splits fructose 1,6-bisphosphate into a ketone and an aldehyde molecule. GAP is the substrate needed for the next step of glycolysis. Both molecules of GAP produced in the previous step undergo this process of dehydrogenation and phosphorylation.
This happens to each molecule of BPG. The enzyme phosphoglyceromutase relocates the P of the two 3 PGA molecules from the third to the second carbon to form two 2-phosphoglycerate 2 PGA molecules. The enzyme enolase removes a molecule of water from 2-phosphoglycerate to form phosphoenolpyruvate PEP. This happens for each molecule of 2 PGA from Step 8. This happens for each molecule of PEP. This reaction yields two molecules of pyruvate and two ATP molecules. That is the end of the five-step preparatory phase, with two ATPs spent to achieve the two phosphorylations.
So altogether it's astep process. The first five steps comprise the preparatory phase , which take one molecule of glucose and produce two molecules of GADP glyceraldehydephosphate.
This will cost 2 ATP. Certainly the main thing to remember is that in glycolysis, glucose in the cytoplasm of the cell is converted into pyruvate, which will then move on to the next stage of cellular respiration, which is TCA Cycle cycle. Email This BlogThis! Share to Twitter Share to Facebook. Newer Post Older Post Home. Popular Posts. Cell cycle is one of the most breathtaking processes that helps the cells to not only grow but also divide.
We now turn to the synthesis of glucose from noncarbohydrate precursors, a process called gluconeogenesis. This metabolic pathway is important because the brain depends on glucose as its primary fuel and red blood cells use only glucose as a fuel. The gluconeogenic pathway converts pyruvate into glucose.
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